Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model

Tobacco smoking is one of the most serious health problems. Potentially lethal effects nicotine for adults can occur with as little 30 to 60 mg, although severe symptoms arise lower doses. Furthermore, route administration also influences toxicity. Cytisine popular medications in nicotinism treatment. Like nicotine, cytisine a plant alkaloid, signaling through nicotinic acetylcholine receptors. Our study evaluated nicotine-induced embryotoxic using zebrafish larvae. We examined teratogenicity and alone or combination. Nicotine increased mortality delayed hatching larvae dose-dependent manner. did not affect wide range concentrations, delay was observed only at highest above 2 mM. Administering compounds together partially reduced adverse teratogenic effect induced by alone. The protective against effect, zebrafish, will contribute future studies treatments related addiction prenatal exposure humans.